dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2021-06-26T06:17:14Z | |
dc.date.accessioned | 2022-12-19T23:08:46Z | |
dc.date.available | 2021-06-26T06:17:14Z | |
dc.date.available | 2022-12-19T23:08:46Z | |
dc.date.created | 2021-06-26T06:17:14Z | |
dc.date.issued | 2021-06-05 | |
dc.identifier | Colloids And Surfaces A-physicochemical And Engineering Aspects. Amsterdam: Elsevier, v. 618, 6 p., 2021. | |
dc.identifier | 0927-7757 | |
dc.identifier | http://hdl.handle.net/11449/210762 | |
dc.identifier | 10.1016/j.colsurfa.2021.126426 | |
dc.identifier | WOS:000642467400002 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5391364 | |
dc.description.abstract | In the present work we evaluated the low-fouling feature of a carboxylic-oligo(ethylene glycol) self-assembled monolayer (carboxylic-OEG-SAM) interface using a quartz crystal microbalance with dissipation monitoring (QCM-D). QCM-D measurements allowed us to estimate the amount of protein loading in two different serum dilutions at two different interfaces: bare gold and carboxylic-OEG. The observed amount of protein adsorbed onto bare gold is about twice higher that of carboxylic OEG interface, confirming the low-fouling characteristics of OEG-modified surfaces. Additionally, QCM-D results demonstrated the existence of two protein adsorption regimes, a faster and a slower, with distinct dissipation energies which was modelled by a two-step kinetic model. The faster regime was attributed to the adsorption of proteins into free sites of the carboxylic-OEG-SAM in a rigid binding process, followed by a slower and more viscoelastic adsorption process ascribed to structural conformational changes; this slower step conforms with the filling of remaining free sites associated with the steric hindrance in which protein-protein interactions defines the slower rate constant for the adsorption. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Colloids And Surfaces A-physicochemical And Engineering Aspects | |
dc.source | Web of Science | |
dc.subject | Low-fouling interfaces | |
dc.subject | QCM-D | |
dc.subject | Molecular dynamics | |
dc.subject | Protein adsorption | |
dc.subject | Self-assembled monolayers | |
dc.title | Low-fouling properties in serum of carboxylic-oligo(ethylene glycol)-based interfaces | |
dc.type | Artículos de revistas | |