Otros
In situ melanoma of oral cavity: Diagnosis and treatment of a rare entity
Fecha
2021-01-01Registro en:
Oral Oncology.
1879-0593
1368-8375
10.1016/j.oraloncology.2020.105116
2-s2.0-85099260583
Autor
Universidade Estadual Paulista (Unesp)
Pathology Institute of Araçatuba
Centro Universitário Católico Unisalesiano Auxilium
Institución
Resumen
Oral melanoma is an extremely aggressive and rare tumor. Commonly, oral melanomas are diagnosed as invasive tumors, which considerably reduces the chances of cure. In situ oral melanomas being exceedingly rare, which makes its clinicopathological and prognostic characteristics poorly known. Herein, we report a case of 67-year-old non-white woman with a large black patch on the maxillary alveolar mucosa. A biopsy was made and microscopical analysis revealed moderate atypical junctional melanocytic. Tumor cells were positive for S100 (Polyclonal), Melan-A (Clone A103) and Melanosome (HMB-45). The diagnosis of in situ oral melanoma was made and the patient was treated surgically with partial maxillectomy and rehabilitated with obturator prosthesis. Although extremely rare in situ melanomas should be considered in the differential diagnosis of non-invasive pigmented lesions of the oral mucosa.