Otros
Prospective application of phthalocyanines in the photodynamic therapy against microorganisms and tumor cells: A mini-review
Fecha
2020-12-01Registro en:
Photodiagnosis and Photodynamic Therapy, v. 32.
1873-1597
1572-1000
10.1016/j.pdpdt.2020.102032
2-s2.0-85094864652
Autor
State University of Paraíba
Universidade Estadual Paulista (Unesp)
Facultad de Química-Universidad de la República (UdelaR)
Institución
Resumen
Phthalocyanines are second-generation photosensitizers with photophysical and photochemical properties improved, in comparison to the first-generation. Also, these have shown to be phototoxic against several types of microorganisms and tumor cells. However, challenges such as low solubility in the physiological environment make its single administration unfeasible. Therefore, this review discusses a unique combination of phthalocyanine-loaded in drug delivery carriers for photodynamic therapy in different pathologies' treatment, including nanoemulsion, liposomes, and lipid nanoparticles in an attempt to overcome low solubility drawback. Furthermore, the latest advances to elucidating its mechanisms of action are shown. Subsequently, the manuscript was divided into ten different types of phthalocyanines for medical applications, with a description of their definitions and applications, summarizing the latest preclinical results founded in recent literature.