dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Botucatu Integrated College (UNIFAC) | |
dc.date.accessioned | 2021-06-25T10:17:38Z | |
dc.date.accessioned | 2022-12-19T22:06:33Z | |
dc.date.available | 2021-06-25T10:17:38Z | |
dc.date.available | 2022-12-19T22:06:33Z | |
dc.date.created | 2021-06-25T10:17:38Z | |
dc.date.issued | 2021-01-15 | |
dc.identifier | Molecular and Cellular Endocrinology, v. 520. | |
dc.identifier | 1872-8057 | |
dc.identifier | 0303-7207 | |
dc.identifier | http://hdl.handle.net/11449/205568 | |
dc.identifier | 10.1016/j.mce.2020.111095 | |
dc.identifier | 2-s2.0-85097235316 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5386165 | |
dc.description.abstract | The literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. However, little is known about the γOz action as a possible agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of this study was to test the hypothesis that γOz attenuates the cytokine storm by stimulating PPAR-γ in the adipose tissue. Methods: Male Wistar rats were randomly divided into three experimental groups and fed ad libitum for 30 weeks with control diet (C, n = 6), high sugar-fat diet (HSF, n = 6) or high sugar-fat diet + γOz (HSF + γOz, n = 6). HSF groups also received water + sucrose (25%). The γOz dose was 0.5% in the chow. Evaluation in animals included caloric intake, body weight, adiposity index, plasma triglycerides, and HOMA-IR. In adipose tissue was evaluated: PPAR-γ gene and protein expression, inflammatory and oxidative stress parameters, and histological analysis. Results: Adipose tissue dysfunction was observed in HSF group, which presented remarkable PPAR-γ underexpression and increased levels of cytokines, other inflammatory markers and oxidative stress. The γOz treatment prevented adipose tissue dysfunction and promoted PPAR-γ overexpression. Conclusion: Natural compounds as γOz can be considered a coadjutant therapy to prevent the cytokine storm in COVID-19 patients with obesity conditions. | |
dc.language | eng | |
dc.relation | Molecular and Cellular Endocrinology | |
dc.source | Scopus | |
dc.subject | COVID-19 | |
dc.subject | Gamma-oryzanol | |
dc.subject | Obesity | |
dc.subject | PPAR-γ | |
dc.title | Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19? | |
dc.type | Artículos de revistas | |