dc.contributorUniversidade de São Paulo (USP)
dc.contributorNational Institute for Space Research (INPE)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:47:50Z
dc.date.accessioned2022-12-19T21:23:30Z
dc.date.available2020-12-12T02:47:50Z
dc.date.available2022-12-19T21:23:30Z
dc.date.created2020-12-12T02:47:50Z
dc.date.issued2020-12-01
dc.identifierMaterials Science and Engineering C, v. 117.
dc.identifier1873-0191
dc.identifier0928-4931
dc.identifierhttp://hdl.handle.net/11449/202021
dc.identifier10.1016/j.msec.2020.111327
dc.identifier2-s2.0-85089415277
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5382655
dc.description.abstractPolymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3–11 μm) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR.
dc.languageeng
dc.relationMaterials Science and Engineering C
dc.sourceScopus
dc.subjectAntimicrobial
dc.subjectBioglass
dc.subjectCarbon nanotubes
dc.subjectGBR
dc.subjectPoly (lactic acid)
dc.titleSynergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration
dc.typeArtículos de revistas


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