Artículos de revistas
Early diagnosis and treatment of Alzheimer’s disease: New definitions and challenges
Fecha
2020-07-01Registro en:
Brazilian Journal of Psychiatry, v. 42, n. 4, p. 431-441, 2020.
1809-452X
1516-4446
10.1590/1516-4446-2019-0735
S1516-44462020000400016
2-s2.0-85086023549
S1516-44462020000400016.pdf
Autor
Universidade de São Paulo (USP)
Pontifícia Universidade Católica de São Paulo (PUC-SP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The prevalence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the ‘‘amyloid cascade’’ and the ‘‘continuum of AD,’’ discussed in this article, are now well established. From updated classifications and recommendations to advances in biomarkers of AD, we aim to critically assess the literature on AD, addressing new definitions and challenges that emerged from recent studies on the subject. Updates on the status of major clinical trials are also given, and future perspectives are discussed.