Artículos de revistas
Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery
Fecha
2020-02-07Registro en:
Pharmaceutical Development and Technology, v. 25, n. 2, p. 159-167, 2020.
1097-9867
1083-7450
10.1080/10837450.2019.1682608
2-s2.0-85075229584
Autor
Universidade Estadual Paulista (Unesp)
University of Albstadt-Sigmaringen
Institución
Resumen
Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18–30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.