Artículos de revistas
Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
Fecha
2020-01-01Registro en:
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 53, 4 p., 2020.
0037-8682
10.1590/0037-8682-0210-2019
S0037-86822020000100623
WOS:000510394200001
S0037-86822020000100623.pdf
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Introduction: Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. Methods: Patients (159) with chronic hepatitis C of both genders were analyzed. Results: Women showed association between HPA-3 polymorphisms and RM. Conclusions: An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.