Otros
Chemical and Biological Characteristics of Antimicrobial alpha-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes
Fecha
2019-10-01Registro en:
Toxins. Basel: Mdpi, v. 11, n. 10, 18 p., 2019.
10.3390/toxins11100559
WOS:000493542500035
Autor
Universidade Estadual Paulista (Unesp)
Butantan Inst
Univ Toyama
Institución
Resumen
Solitary wasps use their stinging venoms for paralyzing insect or spider prey and feeding them to their larvae. We have surveyed bioactive substances in solitary wasp venoms, and found antimicrobial peptides together with some other bioactive peptides. Eumenine mastoparan-AF (EMP-AF) was the first to be found from the venom of the solitary eumenine wasp Anterhynchium flavomarginatum micado, showing antimicrobial, histamine-releasing, and hemolytic activities, and adopting an alpha-helical secondary structure under appropriate conditions. Further survey of solitary wasp venom components revealed that eumenine wasp venoms contained such antimicrobial alpha-helical peptides as the major peptide component. This review summarizes the results obtained from the studies of these peptides in solitary wasp venoms and some analogs from the viewpoint of (1) chemical and biological characterization; (2) physicochemical properties and secondary structure; and (3) channel-like pore-forming properties.