Artículos de revistas
Electrochemical reduction and cathodic stripping voltammetric determination of clotrimazole
Fecha
2001-01-01Registro en:
Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 12, n. 2, p. 202-207, 2001.
0103-5053
WOS:000168263300013
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The reduction of clotrimazole at a mercury electrode, in phosphate buffer, pH>6, involves a reversible one-electron process. The electrochemical process presents a large contribution from adsorption effects. For the differential pulse polarographic determination the addition of Triton X-100 is recommended. Clotrimazole can be determined by cathodic stripping voltammetry at 50 ng mL(-1) level when pre-accumulated for 3 min at an accumulation potential of -0.20 V. The proposed method is applied successfully for the determination of clotrimazole in a commercial formulation.