Artículos de revistas
A nanoscale redox-active composite as a low-fouling interface for capacitive assaying
Fecha
2019-07-15Registro en:
Sensors and Actuators, B: Chemical, v. 291, p. 493-501.
0925-4005
10.1016/j.snb.2019.01.164
2-s2.0-85061456424
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
An electro-active nanoscale composite was engineered to serve as an alternative to monolayers in a capacitive biosensing platform. An electrochemical impedance-derived spectroscopic method was applied to analyse the response of this nanoscale (c.a. 9 nm thickness) composite to detect C-reactive protein. The composite was successfully assembled over a conductive electrode and built up by conjugating graphene oxide sheets into a self-assembled 11-ferrocenyl-undecanethiol structure, forming a molecular composite concomitantly coated with zwitterionic methacrylate-based monomers that served as the non-fouling component of the composite. Finally, the functionalization of a composite with receptors allowed the successful testing of its electro-analytical ability to detect C-reactive protein in both phosphate-buffered saline and neat human serum samples.