Artículos de revistas
Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Fecha
2019-10-01Registro en:
Medical mycology, v. 57, n. 7, p. 900-904, 2019.
1460-2709
10.1093/mmy/myy112
2-s2.0-85072148051
2402682969776875
0000-0001-7015-7175
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.