Artículos de revistas
Vancomycin removal during high-volume peritoneal dialysis in acute kidney injury patients
Fecha
2019-03-01Registro en:
Peritoneal Dialysis International, v. 39, n. 2, p. 183-187, 2019.
1718-4304
0896-8608
10.3747/pdi.2018.00092
2-s2.0-85062832421
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
University of San Diego
Institución
Resumen
Studies on vancomycin pharmacokinetics in acute kidney injury (AKI) patients on high-volume peritoneal dialysis (HVPD) are lacking. We studied the pharmacokinetics of intravenous (IV) vancomycin in AKI patients treated by HVPD who received a prescribed single IV dose of vancomycin (15 – 20 mg/kg total body weight) to determine the extent of vancomycin removal and to establish vancomycin dosing guidelines for the empirical treatment of AKI patients receiving HVPD. The application of 18 mg/kg vancomycin every 48 – 72 hours in AKI patients undergoing HVPD was required to maintain therapeutic concentrations.