es | en | pt | fr
    • Presentation
    • Countries
    • Institutions
    • Get involved
        JavaScript is disabled for your browser. Some features of this site may not work without it.
        View Item 
        •   Home
        • Brasil
        • Universidades
        • Universidade Estadual de Campinas (Brasil)
        • View Item
        •   Home
        • Brasil
        • Universidades
        • Universidade Estadual de Campinas (Brasil)
        • View Item

        Antimicrobial activity of statins against bacteria of the oral microbiota

        Registration in:
        https://doi.org/10.25824/redu/ZHOMPF
        https://repositorioslatinoamericanos.uchile.cl/handle/2250/5363175
        Author
        Carvalho, Rafaela Durrer Parolina de
        Moreno, Jéssica de Andrade
        Roque, Sindy Magri
        Chan, Daniel Cheuk Hong
        Torrez, Willy Bustillos
        Stipp, Rafael Nobrega
        Bueno-Silva, Bruno
        Lima, Patrícia Oliveira de
        Müller, Karina Cogo
        Institutions
        • Universidade Estadual de Campinas (Brasil)
        Abstract
        Objectives: to investigate the antimicrobial activity of atorvastatin, pravastatin, rosuvastatin, and simvastatin against oral bacteria, and the interaction of SMV with standard antimicrobials (amoxicillin and metronidazole). Methods: Minimal inhibitory concentration assays were performed with Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Actinomyces odontolyticus, Streptococcus oralis, Streptococcus mitis, Streptococcus salivarius, Streptococcus sanguinis, and Streptococcus gordonii; checkerboard microdilution assays between simvastatin and standard antimicrobials; monospecies and multispecies biofilms. Results: simvastatin showed the best antimicrobial activity against most species (MIC range from 3.12 to 25 µg/mL), highlighting the sensitivity of P. gingivalis. In the checkerboard assay, synergistic interaction was found between simvastatin and amoxicillin against S. oralis and S. sanguinis. P. gingivalis biofilm was inhibited by simvastatin at 10 and 50x Minimal inhibitory concentration, with similar effects to metronidazole. For multispecies biofilm, SMV reduced the biofilm metabolic activity (79%) and total counts (87%), comparable to amoxicillin. simvastatin also reduced bacterial counts of Veilonnella parvula, P. gingivalis, Streptococcus mutans, Actinomyces naeslundii, P. intermedia, and Capnocytophaga ochracea in the multispecies biofilm. Conclusions: Simvastatin showed antimicrobial and antibiofilm activity against oral bacteria and may contribute to the control of dysbiosis, and may be considered in clinical studies as an adjuvant in the treatment of periodontitis.
        Subjects
        Chemistry
        Medicine, Health and Life Sciences
        Statins
        Simvastatin
        Drug repositioning
        Periodontal diseases
        Antimicrobial agents

        Show full item record


        Red de Repositorios Latinoamericanos
        + of 8.000.000
        Available publications
        500 Participating institutions
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Membership Login
        Featured collections
        • Latin American Theses
        • Argentinean Theses
        • Chilean Theses
        • Peruvian Theses
        Latest collections added
        • Argentina
        • Brazil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018
         

        EXPLORE BY

        Institutions
        Date2011 - 20202001 - 20101951 - 20001901 - 19501800 - 1900

        Browse in Repository Network

        Countries >
        Document type >
        Publication date >
        Institutions >

        Red de Repositorios Latinoamericanos
        + of 8.000.000
        Available publications
        500 Participating institutions
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Membership Login
        Featured collections
        • Latin American Theses
        • Argentinean Theses
        • Chilean Theses
        • Peruvian Theses
        Latest collections added
        • Argentina
        • Brazil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018