Analysis of the effects of simvastatin on the mevalonate pathway, cell wall integrity and bacterial metabolome: evidence of the antimicrobial mechanism of action
Autor
Sousa, Iago Torres Cortês de
Silva, Kátia de Pádua
Müller, Karina Cogo
Institución
Resumen
These data are the result of research carried out to investigate the antimicrobial action mechanism of simvastatin against S. aureus. Analyzes were performed to verify changes in gene expression, cell wall integrity, metabolome, proteome and HMG-CoA-reductase II enzyme.