The Salamangone deposit occurs in the Lourenço Gold District, Amapá. It is associated to Paleoproterozoic metamorphosed supracrustal rocks and a calc-alkaline complex. The deposit lies within a metaluminous to weakly peraluminous, calc-alkaline tonaliticgranodioritic pluton. The Au-mineralization consists of an epigenetic quartz-vein system, enriched in Au and As, and structurally controlled by a ductile-brittle shear zone. U-Pb zircon analyses of tonalite gave a crystallization age of 2.16 ± 0.13Ga, whereas Sm-Nd TDM model ages of tonalite and granodiorite range from 2.24 and 2.34Ga. eNd(T) vary from +2.88 to +3.02. Additional whole rock Rb-Sr isochron ages on granitoids yielded values in the range of 2.17 to 2.28Ga, with 87Sr/86Sr initial ratio of 0.702. The isotopic data and geochemical signature of granitoids suggest that the Lourenço region, as well as the neighboring areas in French Guyana, represents a vast area largely floored by accreted juvenile arc terranes without evidence of Archean crust contamination, being related to the development of a calc-alkaline magmatic arc, which was produced within the Maroni-Itacaíunas Province, during a major Paleoproterozoic orogenic event.The Salamangone deposit occurs in the Lourenço Gold District, Amapá. It is associated to Paleoproterozoic metamorphosed supracrustal rocks and a calc-alkaline complex. The deposit lies within a metaluminous to weakly peraluminous, calc-alkaline tonaliticgranodioritic pluton. The Au-mineralization consists of an epigenetic quartz-vein system, enriched in Au and As, and structurally controlled by a ductile-brittle shear zone. U-Pb zircon analyses of tonalite gave a crystallization age of 2.16 ± 0.13Ga, whereas Sm-Nd TDM model ages of tonalite and granodiorite range from 2.24 and 2.34Ga. eNd(T) vary from +2.88 to +3.02. Additional whole rock Rb-Sr isochron ages on granitoids yielded values in the range of 2.17 to 2.28Ga, with 87Sr/86Sr initial ratio of 0.702. The isotopic data and geochemical signature of granitoids suggest that the Lourenço region, as well as the neighboring areas in French Guyana, represents a vast area largely floored by accreted juvenile arc terranes without evidence of Archean crust contamination, being related to the development of a calc-alkaline magmatic arc, which was produced within the Maroni-Itacaíunas Province, during a major Paleoproterozoic orogenic event.