Evaluation of Cardiopulmonary biomarkers during different stages of Canine Visceral Leishmaniasis

Evaluación de biomarcadores cardiopulmonares durante diferentes etapas de Leishmaniasis visceral canina

dc.creatorCanberh, Balikci
dc.creatorKerem, Ural
dc.date2018-01-10
dc.date.accessioned2022-12-15T14:42:51Z
dc.date.available2022-12-15T14:42:51Z
dc.identifierhttps://revistamvz.unicordoba.edu.co/article/view/1236
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5353256
dc.descriptionObjective.The purpose of the present study was to test the hypothesis that cardiac alterations participate within different stages of CVL. Materials and methods. Dogs were diagnosed with CVL, were classified as follows; group I (mild disease), group II (moderate disease), group III (severe disease), group IV (very severe disease) and group V included healthy controls. Results. Ig G antibodies against Leishmaniasis in group as tested by IFAT, were deemed 1/64 to 1/16000 among infected groups. Considering the cTnI levels, there was significant differences (p=0.018) between stage IV (group IV) and healthy control group, besides between group IV and group I. Considering D-dimer levels, there was difference between healthy control group and group II, III and IV (p=0.005). NT-proBNP levels, there was istatistical difference between healthy control group and stage III, IV, besides between stage I with stage III, IV (p=0.000). Conclusions. The results showed that levels of cTnI, Nt pro-BNP and D-dimer were higher in dogs infected with CVL in contrast to healthy dogs, in which levels of those biomarkers were below detection limits. Obtained results suggested the possibility of cTnI and NT pro-BNP as markers for cardiac damage and D-dimer as a supportive tool for a diagnosis of probable thromboembolism in dogs with CVL.en-US
dc.descriptionObjetivo. El propósito del presente estudio fue probar la hipótesis de que las alteraciones cardíacas participan en diferentes estadios de CVL. Materiales y métodos. Perros fueron diagnosticados con CVL, se clasificaron de la siguiente manera; Grupo I (enfermedad leve), grupo II (enfermedad moderada), grupo III (enfermedad grave), grupo IV (enfermedad muy grave) y grupo V controles sanos incluidos. Resultados. Los anticuerpos Ig G contra la leishmaniasis en el grupo como probado por IFAT, se consideraron 1/64 a 1/16000 entre los grupos infectados. Considerando los niveles de cTnI, hubo diferencias significativas (p=0,018). Entre el grupo IV y el grupo control sano, además entre el grupo IV y el grupo I. Considerando los niveles D-dímero, hubo diferencia entre el grupo control sano y el grupo II, III y IV (p=0,005). Teniendo en cuenta los niveles de NT-proBNP, hubo diferencia estadística entre el grupo de control sano y el estadio III, IV, además entre la etapa I con estadio III, IV (p=0,000). Conclusiones. Los resultados mostraron que los niveles de cTnI, Nt pro-BNP y D-dímero fueron mayores en perros infectados con CVL en contraste con perros sanos, en los que los niveles de estos biomarcadores estaban por debajo de los límites de detección. Los resultados obtenidos sugirieron la posibilidad de que cTnI y NT pro-BNP como marcadores de daño cardíaco y D-dímero como una herramienta de apoyo para un diagnóstico de tromboembolismo probable en perros con CVL.es-ES
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dc.languagespa
dc.publisherUniversidad de Córdobaes-ES
dc.relationhttps://revistamvz.unicordoba.edu.co/article/view/1236/pdf
dc.relationhttps://revistamvz.unicordoba.edu.co/article/view/1236/2471
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dc.sourceJournal MVZ Cordoba; Vol. 23 No. 1 (2018): Revista MVZ Córdoba Volumen 23(1) Enero-abril 2018; 6403-6413en-US
dc.sourceRevista MVZ Córdoba; Vol. 23 Núm. 1 (2018): Revista MVZ Córdoba Volumen 23(1) Enero-abril 2018; 6403-6413es-ES
dc.source1909-0544
dc.source0122-0268
dc.subjectCanine Visceral Leishmaniasisen-US
dc.subjectcTnIen-US
dc.subjectD-dimeren-US
dc.subjectNT-proBNPen-US
dc.subjectLeishmaniasis Visceral Caninaes-ES
dc.subjectcTnIes-ES
dc.subjectD-dímeroes-ES
dc.subjectNT-proBNPes-ES
dc.titleEvaluation of Cardiopulmonary biomarkers during different stages of Canine Visceral Leishmaniasisen-US
dc.titleEvaluación de biomarcadores cardiopulmonares durante diferentes etapas de Leishmaniasis visceral caninaes-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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