| dc.description.abstract | Antimicrobial activity of leaf extract of zabila (Aloe vera L.) in growth of clinical microbes
The zabila is a plant of great medical and pharmaceutical interest, for its various and numerous medicinal properties in diseases of different origin, corroborating the effect
in vitro and in vivo of extracts. This study evaluated the antimicrobial activity
with macro dilution method, in the ethanol extract of Aloe vera leaf (5-80%),qualitatively by the turbidity of the culture in liquid medium and quantitatively in colony forming units (CFU) on solid medium. Determined the minimum inhibitory concentration (MIC),
bactericidal (BIC) and fungicidal (FIC), in 50 uL of the inoculum of microorganisms of clinical interest such as Candida albicans
complex, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus
at 37°C for 24 and 48 h. Found that at
24 hours, MIC was 35, 40 and 55% and BIC was 40, 45 and 60% for E. coli, P. aeruginosa
and S. aureus , respectively, whereas
C. albicans , the MIC and MFC were 55 and 60% respectively. After 48 hours of culture MIC was 30, 35 and 25% and BIC was 35, 40 and 30% for E. coli, P. aeruginosa and
S. aureus, respectively, whereas C. albicans
, the MIC and MFC were 40 and 45% respectively. The 48 h exposure to the leaf extract of Aloe vera L has great potential biocide for these clinically important
microorganisms, can be effectively used in the production of generic drugs of low economic value to treat conditions caused by
them in the future, once the legal validation
in vivo , allowing their final commercial use are made. | |
