info:eu-repo/semantics/article
Diastereoselective Synthesis of Dihydroisoindolo[2,1‑a]quinolin-11- ones by Solvent-Free AMCell-SO3H‑Catalyzed Imino Diels−Alder/Intramolecular Amide Cyclization Cascade Reactions
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Contiene 37 referencias bibliográficas. Véase documento adjunto
10.1021/jo500516c
Autor
Merchan Arenas, Diego Rolando
Kouznetsov, Vladimir V.
Resumen
Nineteen bioactive highly functionalized 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)-one derivatives were easily prepared in good yield without solvent using catalytic amorphous milled cellulose sulfonic acid (AMCell-SO3H), substituted anilines, propenyl-phenols, and phthaldehydic acid. The cascade reaction gave high regioselectivity and diastereoselectivity. Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias 5507-543-31904 Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana no