Synthesis, biological evaluation, and molecular simulation of chalcones and aurones as selective MAO-B inhibitors

Article

Fecha

2015

Registro en:

85, 6, 685-695

17470277

https://hdl.handle.net/20.500.12728/5432

https://repositorioslatinoamericanos.uchile.cl/handle/2250/5146828

Autor

Morales-Camilo N.

Salas C.O.

Sanhueza C.

Espinosa-Bustos C.

Sepúlveda-Boza S.

Reyes-Parada M.

Gonzalez-Nilo F.

Caroli-Rezende M.

Fierro A.

Institución

Universidad Autónoma de Chile

Materias

molecular modeling

monoamine oxidase inhibitors

1 (2 hydroxy 5 methoxyphenyl) 3 (2,4,5 trimethoxyphenyl)prop 2 en 1 one

1 (2 hydroxy 6 methoxyphenyl) 3 (2,4,5 trimethoxyphenyl)prop 2 en 1 one

2 (2,3 dimethoxybenzylidene) 4 methoxybenzofuran 3(2h) one

2 (2,3 dimethoxybenzylidene) 5 methoxybenzofuran 3(2h) one

2 (2,4,5 trimethoxybenzylidene) 4 methoxybenzofuran 3(2h) one

2 (2,4,5 trimethoxybenzylidene) 5 methoxybenzofuran 3(2h) one

2 (2,5 dimethoxybenzylidene) 4 methoxybenzofuran 3(2h) one

2 (2,5 dimethoxybenzylidene) 5 methoxybenzofuran 3(2h) one

2 (4 bromo 2,5 dimethoxybenzylidene) 4 methoxybenzofuran 3(2h) one

2 (4 bromo 2,5 dimethoxybenzylidene) 5 methoxybenzofuran 3(2h) one

3 (2,3 dimethoxyphenyl) 1 (2 hydroxy 5 methoxyphenyl)prop 2 en 1 one

3 (2,3 dimethoxyphenyl) 1 (2 hydroxy 6 methoxyphenyl)prop 2 en 1 one

3 (2,5 dimethoxyphenyl) 1 (2 hydroxy 5 methoxyphenyl)prop 2 en 1 one

3 (2,5 dimethoxyphenyl) 1 (2 hydroxy 6 methoxyphenyl)prop 2 en 1 one

3 (4 bromo 2,5 dimethoxyphenyl) 1 (2 hydroxy 5 methoxyphenyl)prop 2 en 1 one

3 (4 bromo 2,5 dimethoxyphenyl) 1 (2 hydroxy 6 methoxyphenyl)prop 2 en 1 one

amine oxidase (flavin containing) isoenzyme B

aurone derivative

chalcone derivative

monoamine oxidase B inhibitor

natural products and their synthetic derivatives

unclassified drug

amine oxidase (flavin containing)

benzofuran derivative

chalcone derivative

monoamine oxidase inhibitor

biological activity

enzyme inhibition

molecular docking

molecular dynamics

molecular mechanics

molecular model

priority journal

quantitative structure activity relation

Molecular Docking Simulation

Monoamine Oxidase

Monoamine Oxidase Inhibitors

Quantitative Structure-Activity Relationship

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