Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

dc.creatorReis J.
dc.creatorCagide F.
dc.creatorValencia M.E.
dc.creatorTeixeira J.
dc.creatorBagetta D.
dc.creatorPérez C.
dc.creatorUriarte E.
dc.creatorOliveira P.J.
dc.creatorOrtuso F.
dc.creatorAlcaro S.
dc.creatorRodríguez-Franco M.I.
dc.creatorBorges F.
dc.date.accessioned2020-09-02T22:27:03Z
dc.date.accessioned2022-11-08T20:25:14Z
dc.date.available2020-09-02T22:27:03Z
dc.date.available2022-11-08T20:25:14Z
dc.date.created2020-09-02T22:27:03Z
dc.date.issued2018
dc.identifier158, , 781-800
dc.identifier02235234
dc.identifierhttps://hdl.handle.net/20.500.12728/6037
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5145578
dc.languageen
dc.publisherElsevier Masson SAS
dc.subjectAChE inhibitors
dc.subjectAlzheimer's disease
dc.subjectChromone
dc.subjectMAO-B inhibitors
dc.subjectMulti-target-directed ligands
dc.subjectNew chemical entities
dc.subject2 (dimethylamino)ethyl (e) 3 [4 oxo 2 (4 methylphenlcarbamoyl) 4h chromen 6 yl]acrylate
dc.subject2 (dimethylamino)ethyl (e) 3 [4 oxo 3 (phenylcarbamoyl) 4h chromen 6 yl]acrylate
dc.subjectcholinesterase inhibitor
dc.subjectchromone derivative
dc.subjectmonoamine oxidase inhibitor
dc.subjectunclassified drug
dc.subjectamine oxidase (flavin containing)
dc.subjectcholinesterase
dc.subjectcholinesterase inhibitor
dc.subjectchromone derivative
dc.subjectligand
dc.subjectmonoamine oxidase inhibitor
dc.subjectAlzheimer disease
dc.subjectArticle
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectenzyme inhibition
dc.subjectIC50
dc.subjectAlzheimer disease
dc.subjectblood brain barrier
dc.subjectchemistry
dc.subjectdrug design
dc.subjectHep-G2 cell line
dc.subjecthuman
dc.subjectmetabolism
dc.subjectmolecular docking
dc.subjectmolecularly targeted therapy
dc.subjectAlzheimer Disease
dc.subjectBlood-Brain Barrier
dc.subjectCholinesterase Inhibitors
dc.subjectCholinesterases
dc.subjectChromones
dc.subjectDrug Design
dc.subjectHep G2 Cells
dc.subjectHumans
dc.subjectLigands
dc.subjectMolecular Docking Simulation
dc.subjectMolecular Targeted Therapy
dc.subjectMonoamine Oxidase
dc.subjectMonoamine Oxidase Inhibitors
dc.titleMulti-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
dc.typeArticle


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