On the anticonvulsant activity of kaurenic acid

dc.creatorDaló, Nelson L
dc.creatorSosa-Sequera, Miriam C
dc.creatorUsubillaga, Alfredo
dc.date2009-11-03
dc.date.accessioned2022-11-05T00:53:47Z
dc.date.available2022-11-05T00:53:47Z
dc.identifierhttps://produccioncientificaluz.org/index.php/investigacion/article/view/28664
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5135707
dc.descriptionKaurenic acid [(-)-kaur-16-en-19-oic acid] is a diterpene isolated from the aerial parts of Espeletia semiglobulata, one of 85 species of Espeletiinae found in Venezuela. Its anticonvulsive activity was studied using two different models of experimental seizures: spinal seizures induced by sudden cooling (SSSC) in amphibians and seizures induced by pentylenetetrazol (PTZ) in mice. In SSSC, kaurenic acid (KA) inhibited the tonic hind-limb extension with an ED50 of 2.5 mg/kg. It was 4-fold more potent than known anticonvulsant drugs such as carbamazepine and phenytoin and 100-fold more potent than valproic acid. However, KA as well as valproic acid were ineffective against the clonic phase of SSSC. In the PTZ-induced seizures, KA at doses of 0.625 and 1.25 mg/kg increased the latency of seizure onset and protected against generalized clonic-tonic seizures by 45% and 65%, respectively. The sedative effects of KA had an ED50 of 8.5 mg/kg in mice and 75 mg/kg in amphibians. This work provides experimental evidence supporting the potential value of kaurenic acid as an anticonvulsive drug.es-ES
dc.formatapplication/pdf
dc.languagespa
dc.publisherUniversidad del Zuliaes-ES
dc.relationhttps://produccioncientificaluz.org/index.php/investigacion/article/view/28664/29379
dc.rightsDerechos de autor 2016 Investigación Clínicaes-ES
dc.sourceInvestigación Clínica; Vol. 48 Núm. 3es-ES
dc.source2477-9393
dc.source0535-5133
dc.titleOn the anticonvulsant activity of kaurenic acides-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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