Chromosome instability in a patient with recurrent abortions

dc.contributorBobadilla-Morales, L., Laboratorio de Citogenetica, Genotoxicidad Y Biomonitoreo Y Clinica de Asesoramiento Genetico, Instituto de Genética Humana Dr. Enrique Corona Rivera, Universidad de Guadalajara, Sierra Mojada #950 S.L., Segundo Nivel, CP 44340, Guadalajara, Jal, Mexico, Unidad de Citogenética, Servicio de Hematología Oncología Pediátrica, OPD Hospital Civil Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico; Cervantes-Luna, M.I., Laboratorio de Citogenetica, Genotoxicidad Y Biomonitoreo Y Clinica de Asesoramiento Genetico, Instituto de Genética Humana Dr. Enrique Corona Rivera, Universidad de Guadalajara, Sierra Mojada #950 S.L., Segundo Nivel, CP 44340, Guadalajara, Jal, Mexico; García-Cobián, T.A., Laboratorio de Genética Humana, Departamento de Fisiología, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Gómez-Meda, B.C., Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico; Ortega De La Torre, C., Laboratorio de Citogenetica, Genotoxicidad Y Biomonitoreo Y Clinica de Asesoramiento Genetico, Instituto de Genética Humana Dr. Enrique Corona Rivera, Universidad de Guadalajara, Sierra Mojada #950 S.L., Segundo Nivel, CP 44340, Guadalajara, Jal, Mexico; Corona-Rivera, J.R., Laboratorio de Citogenetica, Genotoxicidad Y Biomonitoreo Y Clinica de Asesoramiento Genetico, Instituto de Genética Humana Dr. Enrique Corona Rivera, Universidad de Guadalajara, Sierra Mojada #950 S.L., Segundo Nivel, CP 44340, Guadalajara, Jal, Mexico; Corona-Rivera, A., Laboratorio de Citogenetica, Genotoxicidad Y Biomonitoreo Y Clinica de Asesoramiento Genetico, Instituto de Genética Humana Dr. Enrique Corona Rivera, Universidad de Guadalajara, Sierra Mojada #950 S.L., Segundo Nivel, CP 44340, Guadalajara, Jal, Mexico, Unidad de Citogenética, Servicio de Hematología Oncología Pediátrica, OPD Hospital Civil Dr. Juan I. Menchaca, Guadalajara, Jalisco, Mexico
dc.creatorBobadilla-Morales, L.
dc.creatorCervantes-Luna, M.I.
dc.creatorGarcia-Cobian, T.A.
dc.creatorGomez-Meda, B.C.
dc.creatorOrtega De La Torre, C.
dc.creatorCorona-Rivera, J.R.
dc.creatorCorona-Rivera, A.
dc.date.accessioned2015-11-19T18:51:52Z
dc.date.accessioned2022-11-02T15:32:20Z
dc.date.available2015-11-19T18:51:52Z
dc.date.available2022-11-02T15:32:20Z
dc.date.created2015-11-19T18:51:52Z
dc.date.issued2009
dc.identifierhttp://hdl.handle.net/20.500.12104/67093
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-67650523442&partnerID=40&md5=00371a9f5481656e2fa01c999e6374d4
dc.identifierhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med5&AN=19658259
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5015231
dc.description.abstractChromosomal aberrations are one of the recognized possible etiologic genetic causes of recurrent spontaneous abortions. Increased chromosome instability without constitutional chromosome abnormalities is uncommon in these couples. In this work we present a non consanguineous healthy couple with recurrent abortions without constitutional chromosome aberrations in which spontaneous and induced chromosome aberrations were observed in the female. Chromosome analysis was performed in the presence of different chromosome damage inductors such as gamma radiation, Uv light, and mitomycin-C. Alterations observed only in the female were: spontaneous and induced tetraradial chromosomes and increased chromosomal damage induced only by gamma radiation. Oral mucosa micronuclei were moderately increased in the female. Chromosome instability associated to abortion is proposed.
dc.relationGenetic Counseling
dc.relation20
dc.relation2
dc.relation153
dc.relation159
dc.relationScopus
dc.relationWOS
dc.relationMEDLINE
dc.titleChromosome instability in a patient with recurrent abortions
dc.typeArticle


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