Complex self-assembly of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) triblock copolymers with long hydrophobic and extremely lengthy hydrophilic blocks

Abstract

This is a report of the "Health Policy and Programs Evaluative Research for Social Change" Ibero-American Symposium held in Guadalajara, Mexico November 1-3, 2006. Attendees represented eight countries, and were associated with NGO's and academic and health services organizations. The most important themes included in the debates were the meaning of qualitative and evaluative health research for social change, the challenges of teaching for change, ethical challenges, and possibilities for making the findings of qualitative research available to different groups or stakeholders (users, policy makers, professionals, and the population as a whole). " 2008 FQS.",,,,,,,,,"http://hdl.handle.net/20.500.12104/40285","http://www.scopus.com/inward/record.url?eid=2-s2.0-44949200120&partnerID=40&md5=1a6cecbd211e8826ae4ca54067db0288",,,,,,"2",,"Forum Qualitative Sozialforschung",,,,"9",,"Scopus",,,,,,"Evaluation; Health; Programs; Qualitative; Research; Social change",,,,,,"Conference report: "Health Policy and Programs Evaluative Research for Social Change". An Ibero-American Symposium",,"Conference Paper" "42047","123456789/35008",,"Sossa-Azuela, J.H., Centro de Investigación en Computación-IPN, Av. Juan de Dios Bátiz, Mexico City, C. P. 07738, Mexico; Cuevas-Jiménez, E.V., Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI), Universidad de Guadalajara, Av. Revolución 1500, Col. Olímpica C.P. 44430 Guadalajara, Jal, Mexico; Zaldivar-Navarro, D., Centro Universitario de Ciencias Exactas e Ingenierías (CUCEI), Universidad de Guadalajara, Av. Revolución 1500, Col. Olímpica C.P. 44430 Guadalajara, Jal, Mexico",,"Sossa-Azuela, J.H.

Cuevas-Jimenez, E.V.

Zaldivar-Navarro, D.",,"2010",,"Most of the proposals to compute the Euler number of a binary image have been designed to work with images composed of squared cells. Only a few of these methods (in the case of images composed of hexagonal cells) have been reported in literature, although it is known that images composed of hexagonal cells do not suffer from the problems of connectivity frequently found in the case of images composed of squared cells. In this paper, a new way to compute the Euler number (E) of a binary image composed of hexagonal cells is presented. For this, the perimeter P of the isolated regions in the image, their contact perimeter P c and the type T of a cell are used to obtain this important invariant. The proposal can be used alone or in combination with other features to describe any binary planar shape composed of hexagonal pixels for its further recognition.",,,,,,,,,"http://hdl.handle.net/20.500.12104/40268","http://www.scopus.com/inward/record.url?eid=2-s2.0-84860851945&partnerID=40&md5=4224b2a44e2e3b1159b9e32a97430b26",,,,,,"3",,"Journal of Applied Research and Technology",,"340

351",,"8",,"Scopus

WOS

ScIELO",,,,,,"Binary image characterization; Contact Perimeter; Euler number or genus; Perimeter; Topological descriptor; Topological invariant / Engineering, Electrical & Electronic; Engineering, Multidisciplinary",,,,,,"Computation of the euler number of a binary image composed of hexagonal cells",,"Article" "42036","123456789/35008",,"Cambón, A., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain; Figueroa-Ochoa, E., Laboratorio de Reología, Departamento de Ingeniería Química, Universidad de Guadalajara, Bolv. M. García Barragán 44430, Jalisco, Mexico; Juárez, J., Departamento de Física, Universidad de Sonora, Rosales y Transversal, 83000 Hermosillo, Sonora, Mexico; Villar-Álvarez, E., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain; Pardo, A., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain; Barbosa, S., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain; Soltero, J.F.A., Laboratorio de Reología, Departamento de Ingeniería Química, Universidad de Guadalajara, Bolv. M. García Barragán 44430, Jalisco, Mexico; Taboada, P., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain; Mosquera, V., Departamento de Física de la Materia Condensada, Grupo de Física de Coloides y Polímeros, 15782-Santiago de Compostela, Spain",,"Cambon, A.

Figueroa-Ochoa, E.

Juarez, J.

Villar-Alvarez, E.

Pardo, A.

Barbosa, S.

Soltero, J.F.A.

Taboada, P.

Mosquera, V.",,"2014",,"Amphiphilic block copolymers have emerged during last years as a fascinating substrate material to develop micellar nanocontainers able to solubilize, protect, transport, and release under external or internal stimuli different classes of cargos to diseased cells or tissues. However, this class of materials can also induce biologically relevant actions, which complement the therapeutic activity of their cargo molecules through their mutual interactions with biologically relevant entities (cellular membranes, proteins, organelles...); these interactions at the same time, are regulated by the nature, conformation, and state of the copolymeric chains. For these reasons, in this paper we investigated the self-assembly process and physico-chemcial properties of two reverse triblock poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers, BO14EO 378BO14 and BO21EO385BO 21, which have been recently found to be very useful as drug delivery nanovehicles and biological response modifiers under certain conditions (A. Cambón et al. Int. J. Pharm. 2013, 445, 47-57) in order to obtain a clear picture of the solution behavior of this class or block copolymers and to understand their biological activity. These block copolymers are characterized by possessing long BO blocks and extremely lengthy central EO ones, which provide them with a rich rheological behavior characterized by the formation of flowerlike micelles with sizes ranging from 20 to 40 nm in aqueous solution and the presence of intermicellar bridging even at low copolymers concentrations as denoted by atomic force microscopy. Bridging is also clearly observed by analyzing the rheological response of these block copolymers both storage and loss moduli upon changes on time, temperature, and or concentration. Strikingly, the relatively wide Poisson distribution of the polymeric chains make the present copolymers behave rather distinctly to conventional associative thickeners. The observed rich rheological behavior and their tunability also make these copolymers promising materials to configure drug gelling depots. " 2014 American Chemical Society.