Article
Chromosome Instability Induced in Vitro with Mitomycin C in Five Seckel Syndrome Patients
Fecha
2010Registro en:
Autor
Martinez-Hernandez, F.
Martinez-Ibarra, J.A.
Catala, S.
Villalobos, G.
De La Torre, P.
Laclette, J.P.
Alejandre-Aguilar, R.
Espinoza, B.
Institución
Resumen
The nucleotide sequences of the cytochrome B gene and the antennal phenotypes were analyzed for the following triatomine species: Triatoma longipennis, Triatoma pallidipennis, and Triatoma picturata, which belong to the Phyllosoma complex. These species inhabit sympatric areas from Talpa de Allende, Autlan de Navarro, and Teocuitatlan de Corona in Jalisco, Mexico. Molecular marker analysis showed that the sympatric individuals are the natural crossbred descendents of different individuals living in close proximity in these natural areas that resulted in mixed populations. The antennal phenotype results are coincident with these genetic findings, which point to the high similitude between all Phyllosoma complex populations analyzed. These data support the hypothesis that these species are morphotypes with chromatic and genetic varieties, which preserves the possibility of natural breeding with fertile descent. In conclusion, our results strongly support the hypothesis that T. pallidipennis, T. longipennis, and T. picturata are subspecies of the Phyllosoma complex. Copyright " 2010 by The American Society of Tropical Medicine and Hygiene.",,,,,,"10.4269/ajtmh.2010.09-0272",,,"http://hdl.handle.net/20.500.12104/43034","http://www.scopus.com/inward/record.url?eid=2-s2.0-72449193513&partnerID=40&md5=6dc7e1aa12da4dd4b781c27ee4b8e809",,,,,,"1",,"American Journal of Tropical Medicine and Hygiene",,"74 82",,"82",,"Scopus WOS",,,,,,,,,,,,"Natural crossbreeding between sympatric species of the Phyllosoma complex (Insecta: Hemiptera: Reduviidae) indicate the existence of only one species with morphologic and genetic variations",,"Article"
"37188","123456789/35008",,"Univ Valle de Atemajac, Univ Guadalajara, Ctr Invest & Estudios Superiores Antropol Social, Guadalajara, Jalisco, Mexico",,"Hernandez, EC",,"2013",,,,,,,,,,"1850-373X","http://hdl.handle.net/20.500.12104/36337",,,"Spanish",,"UNIV NAC CENTRO PROVINCIA BUENOS AIRES",,"2",,"INTERSECCIONES EN ANTROPOLOGIA",,"423 432",,"14",,"WOS",,,,,,,,,,,,"WHO IS ABLE TO OR WHO MUST TAKE CARE OF CHILDREN? THE SOCIAL CONSTRUCTION OF CHILD CARE.",,"Article"
"41825","123456789/35008",,"Bobabilla-Morales, L., Departamento de Fisiología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Departamento de Genetica Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Departamento de Fisiología, Ctro. Univ. Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada #950 S.L., CP 44340, Guadalajara, Jal., Mexico; Corona-Rivera, A., Departamento de Fisiología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, Unidad de Citogenética, OPD, Hosp. Civ. Guadalajara F. A. Alcalde, Guadalajara, Jalisco, Mexico, Departamento de Genetica Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Corona-Rivera, J.R., Departamento de Fisiología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, División de Pediatría, OPD, Hosp. Civ. Guadalajara J.I. Menchaca, Guadalajara, Jalisco, Mexico; Buenrostro, C., Hospital General Regional 46, IMSS, Guadalajara, Jalisco, Mexico; García-Cobián, T.A., Departamento de Fisiología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Corona-Rivera, E., Departamento de Fisiología, Ctro. Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico; Cantú-Garza, J.M., División de Genética, Ctro. Invest. Biomed. Occidente, CMNO, Guadalajara, Jalisco, Mexico; García-Cruz, D., Departamento de Genetica Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, División de Genética, Ctro. Invest. Biomed. Occidente, CMNO, Guadalajara, Jalisco, Mexico",,"Bobabilla-Morales, L. Corona-Rivera, A. Corona-Rivera, J.R. Buenrostro, C. García-Cobian, T.A. Corona-Rivera, E. Cantu-Garza, J.M. García-Cruz, D.",,"2003",,"Seckel syndrome (SS) is an autosomal recessive entity characterized by proportionate pre- and post-natal growth retardation, microcephaly, typical facial appearance with beak-like protrusion, and severe mental retardation. A heterogeneous basis for SS was proposed since around 25% of SS patients have hematological anomalies, suggesting a subgroup of SS with chromosome instability and hematological disorders. Chromosome instability induced by mitomycin C (MMC) has been observed in previous reports. The purpose of this study is to report cytogenetic features in five patients with SS. The patients had low birth weight (mean 1,870 g), short stature (SD = 6.36), microcephaly (OFC, SD = 8.1), typical facial appearance, and multiple articular dislocations. None of them had anemia at the time of examination. In all cases their parents were healthy and non-consanguineous. Lymphocytes of SS patients and a control group (n = 9) matched by age and sex were cultured with and without MMC, and harvested at 72 and 96 hr. Chromosomal aberrations (chromatid and chromosomal gaps and breaks, deletions, fragments, and exchanges) were scored in 100 metaphases per culture. A statistical increase of chromosomal aberrations was observed in 96 hr MMC cultures in all patients (40.2% vs. 2.8%). Sister chromatid exchanges were also performed with no differences between groups. Clinical and cytogenetic findings support the idea that SS may correspond to a chromosome instability syndrome. " 2003 Wiley-Liss, Inc.