Artículo
Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review
Fecha
2021Registro en:
González González, R, Ortiz Sarabia, G, Molina Frechero, N, y otros. "Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review". Cancers 2021. [en línea] 2021 Vol,13 .doi.org/10.3390/cancers13123027
doi.org/10.3390/cancers13123027
Autor
González González, Rogelio
Ortiz Sarabia, Gamaliel
Molina Frechero, Nelly
Salas Pacheco, José Manuel
Salas Pacheco, Sergio Manuel
Lavalle Carrasco, Jesús
López Verdin, Sandra
Tremillo Maldonado, Omar
Bologna Molina, Ronell
Institución
Resumen
Head and neck squamous cell carcinomas (HNSCCs) are aggressive, recurrent, and metastatic neoplasms with a high occurrence around the world and can lead to death when not treated appropriately. Several molecules and signaling pathways are involved in the malignant conversion process. Epithelial–mesenchymal transition (EMT) has been described in HNSCCs, a major type of aggressive carcinoma. EMT describes the development of epithelial cells into mesenchymal cells, which depends on several molecular interactions and signaling pathways that facilitate mesenchymal
conversion. This is related to interactions with the microenvironment of the tumor, hypoxia, growth factors, matrix metalloproteinases, and the presence of viral infections. In this review, we focus on the main molecules related to EMT, their interactions with the tumor microenvironment, plasticity phenomena, epigenetic regulation, hypoxia, inflammation, their relationship with immune cells, and the inhibition of EMT in the context of HNSCCs