There are several prognostic factors of clinico-pathologic colorectal carcinoma, including age, sex, tumor location, tumor size, histopathologic type, differentiation grade, depth of invasion, lymph node involvement, and KRAS / NRAS mutations status. This study aims to determine the correlation between KRAS / NRAS mutation status with some clinicopathologic prognostic factors. This research is an observational cross-sectional comparative study design using 24 samples.