Breast cancer is the most common cancer in the world and a leading cause of death in women. This cancer is the major cause of mortality and morbidity in Indonesian women. This study aims to investigate the correlation of Her-2 expression with a clinicopathological profile in invasive ductal breast cancer. This study was retrospective in design. Histopathological diagnosis and immunohistochemical ER, PR, and Her2 from 95 patients with invasive ductal breast cancer were included during the period January 2017 to June 2018.