| dc.creator | Hung, J. | |
| dc.creator | Castillo, Jimmy | |
| dc.creator | Jiménez, G. | |
| dc.creator | Hasegawa, Masahisa | |
| dc.creator | Rodríguez, María del C. | |
| dc.date | 2017-01-20T15:07:13Z | |
| dc.date | 2017-01-20T15:07:13Z | |
| dc.date | 2003 | |
| dc.date.accessioned | 2022-10-28T01:20:11Z | |
| dc.date.available | 2022-10-28T01:20:11Z | |
| dc.identifier | Spectrochimica Acta Part A 59 (2003) 3177 | |
| dc.identifier | 1386-1425 | |
| dc.identifier | http://hdl.handle.net/10872/14067 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4947709 | |
| dc.description | In this work we present spectroscopic study of Boldine (aporphine alkaloid) that possesses important biological
activities, in particular, in interaction with the promastigotes of Leishmania mexicana. The results show the
applicability of autofluorescence of this drug to determinate the possible mechanism of its biological action. The
blue shift and hyperchromic effect in the emission spectrum of the drug in interaction with the parasite cells indicate an
energy transference process between them. The morphological change of cell shape of the promastigotes treated with
the drug is observed using confocal microscopy. This morphological cell-shape transformation evidences an important
interaction between the drug studied and some protein of the parasite cell. Here we describe for the first time the
fluorescence properties of the Boldine in the promastigotes of L. mexicana. | |
| dc.language | en | |
| dc.publisher | Spectrochimica Acta Part A | |
| dc.subject | Boldine | |
| dc.subject | Leishmania mexicana | |
| dc.subject | FRET | |
| dc.title | Spectroscopic study of antileishmanial drug incubated in the promastigotes of Leishmania mexicana | |
| dc.type | Article | |
