Usually the mechanical condition and the induced electric signal are devoted to be part of the stimuli controlling the biophysical activity associate with healing and remodelling phenomena. The tissue differentiation theory proposed by Claes and Heigele (1999) has been numerically implemented using an poroelastic boundary element framework to characterises fracture healing, leading to a new poroelastic correlation between mechanical conditions and local tissue formation. This paper also presents the implementation of the piezoelectric boundary integral equation to further study the bone tissue behaviour. The results were in good agreement with those reported in previous works.Support by Académia de Ciencias Físicas, Matématicas y Naturales de Venezuela, Fondo Nacional de Ciencia, Tecnología e Innovación (FONACIT) and Consejo de Desarrollo Cientifíco y Humanistico (CDCH), UCV, is gratefully acknowledged.