Article
Novel anti-in£ammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages
Chalcones
Autor
Herencia, Felipe
Ferrandiz, Ma. L
Ubeda, Amalia
Gullén, Isabel
Dominguez, Jose
Charris, Jaime
Lobo, Gricela
Institución
Resumen
In a previous work, we tested a series of chalcone
derivatives as possible anti-inflammatory compounds. We now
investigate the effects of three of those compounds, CH1, CH8
and CH12, on nitric oxide and prostanoid generation in mouse
peritoneal macrophages stimulated with lipopolysaccharide and
in the mouse air pouch injected with zymosan, where they showed
a dose-dependent inhibition with inhibitory concentration 50%
values in theWM range. This effect was not the consequence of a
direct inhibitory action on enzyme activities. Our results
demonstrated that chalcone derivatives inhibited de novo
inducible nitric oxide synthase and cyclooxygenase-2 synthesis,
being a novel therapeutic approach for inflammatory diseases