info:eu-repo/semantics/article
Cytokines and t-lymphocyte count in patients in the acute and chronic phases of bartonella bacilliformis infection in an endemic area in Peru: A pilot study
Fecha
2011Institución
Resumen
Human Bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. This cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with Human Bartonellosis. Patients between five and 60 years of age, from endemic areas in Peru, in the acute or chronic phases were included. In patients in the acute phase of Bartonellosis a state of immune peripheral tolerance should be established for persistence of the infection. Our findings were that elevation of the anti-inflammatory cytokine IL-10 and numeric abnormalities of CD4+ and CD8+ T-Lymphocyte counts correlated significantly with an unfavorable immune state. During the chronic phase, the elevated levels of IFN-γ and IL-4 observed in our series correlated with previous findings of endothelial invasion of B. henselae in animal models. La Bartonelosis Humana, tiene una fase aguda caracterizada por fiebre y anemia hemolítica, así como una fase crónica con lesiones semejantes a angiomatosis bacilar. En un estudio transversal piloto los patrones inmunológicos en pacientes con Bartonelosis Humana fueron estudiados mediante muestras pre y post tratamiento. Pacientes entre 5 y 60 años en fase aguda y crónica fueron incluidos en área endémica del Perú. En aquellos pacientes con fase aguda, una fase de tolerancia inmunológica periférica es necesaria para la persistencia de la infección. Los hallazgos de significativa elevación de citoquina anti-inflamatoria (IL-10) y anormalidades numéricas en el recuentos de Linfocitos T CD4+ y CD8+ correlacionan con un estado inmune que favorece la infección. Durante la fase crónica, elevados niveles de INF-γ y IL-4 observados en la serie de pacientes correlacionan con previos hallazgos en modelos animales que favorecen la invasión del endotelio por B. henselae.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Bovine herpesvirus-5 infection in a rabbit experimental model: Immunohistochemical study of the cellular response in the CNS
Machado, Gisele Fabrino; Bernardi, Fernanda; Hosomi, Fernando Y.M.; Peiró, Juliana Regina; Weiblen, Rudi; Roehe, Paulo M.; Alessi, Antonio C.; Melo, Guilherme D.; Ramos, Adriano T.; Maiorka, Paulo C. -
Bovine herpesvirus-5 infection in a rabbit experimental model: Immunohistochemical study of the cellular response in the CNS
Universidade Estadual Paulista (Unesp); Faculdade de Medicina Veterinária e Zootecnia; Departamento de Medicina Veterinária Preventiva; Instituto de Ciências Básicas da Saúde; Curso de Medicina Veterinária (2013-04-01)Since little information is available regarding cellular antigen mapping and the involvement of non-neuronal cells in the pathogenesis of bovine herpesvirus type 5 (BHV-5) infection, it were determined the BHV-5 distribution, ... -
Bovine herpesvirus-5 infection in a rabbit experimental model: Immunohistochemical study of the cellular response in the CNS
Universidade Estadual Paulista (Unesp); Faculdade de Medicina Veterinária e Zootecnia; Departamento de Medicina Veterinária Preventiva; Instituto de Ciências Básicas da Saúde; Curso de Medicina Veterinária (2013-04-01)Since little information is available regarding cellular antigen mapping and the involvement of non-neuronal cells in the pathogenesis of bovine herpesvirus type 5 (BHV-5) infection, it were determined the BHV-5 distribution, ...