Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru

dc.date.accessioned2022-01-18T19:26:48Z
dc.date.available2022-01-18T19:26:48Z
dc.date.created2022-01-18T19:26:48Z
dc.date.issued2012
dc.identifierhttps://hdl.handle.net/20.500.12866/10892
dc.identifierhttps://doi.org/10.1016/j.trstmh.2012.05.008
dc.description.abstractThe effectiveness of the World Health Organization's (WHO) treatment category II regimen for tuberculosis in 124 patients was compared to that of 1147 patients receiving treatment category I in Lima, Peru following WHO's guidelines. Drug susceptibility test was available for 85% of patients. Prevalence of multi drug resistance and streptomycin resistance were 5.1% and 20.7%, respectively. Overall cure rate for regimen II was lower than that of regimen I: 67.8% (95% CI: 58.9-75.6.) vs 77.8% (95% CI: 75.3-80.2), p = 0.014. Multi-drug resistance exerted a profound effect on cure rates in both regimens. Our results support the phasing-out of treatment category II regimen in Peru.
dc.languageeng
dc.publisherOxford University Press
dc.relationTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.relation1878-3503
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHumans
dc.subjectPeru
dc.subjectMajor Clinical Study
dc.subjectRifampicin
dc.subjectPrevalence
dc.subjectTuberculosis
dc.subjectLung Tuberculosis
dc.subjectTuberculosis Pulmonary
dc.subjectTreatment Outcome
dc.subjectAntitubercular Agents
dc.subjectStreptomycin
dc.subjectTuberculosis Multidrug-Resistant
dc.subjectDrug Administration Schedule
dc.subjectWorld Health Organization
dc.subjectMultidrug Resistance
dc.subjectDrug Therapy
dc.subjectPractice Guidelines As Topic
dc.subjectTreatment Failure
dc.subjectEvidence-Based Medicine
dc.subjectConvalescence
dc.subjectTreatment Outcome
dc.subjectFailure
dc.titleAdditional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru
dc.typeinfo:eu-repo/semantics/article


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