info:eu-repo/semantics/article
Identification of Strain-Specific B-cell Epitopes in Trypanosoma cruzi Using Genome-Scale Epitope Prediction and High-Throughput Immunoscreening with Peptide Arrays
Fecha
2013Institución
Resumen
The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clinical forms of the disease by using hemoculture and/or PCR-based genotyping of parasites from infected human tissues. However, both techniques have limitations that hamper the analysis of large numbers of samples. The goal of this work was to identify conserved and polymorphic linear B-cell epitopes of T. cruzi that could be used for serodiagnosis and serotyping of Chagas disease using ELISA.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
QSPR-Perturbation Models for the Prediction of B-Epitopes from Immune Epitope Database: A Potentially Valuable Route for Predicting “In Silico” New Optimal Peptide Sequences and/or Boundary Conditions for Vaccine Development
Vázquez Prieto, Severo; Paniagua Crespo, María Esperanza; Ubeira, Florencio M.; González Díaz, Humberto (Springer, 2016-12)In the present study, three different physicochemical molecular properties for peptides were calculated using the program MARCH-INSIDE: atomic polarizability, partition coefficient, and polarity. These measures were used ... -
Identification of cross-reactive B-cell epitopes between Bos d 9.0101(Bos Taurus) and Gly m 5.0101 (Glycine max) by epitope mapping MALDI-TOF MS
Candreva, Ángela María; Ferrer Navarro, Mario; Bronsoms, Silvia; Quiroga, Alejandra Viviana; Curciarello, Renata; Cauerhff, Ana; Petruccelli, Silvana; Docena, Guillermo H.; Trejo, Sebastian Alejandro (Wiley VCH Verlag, 2017-08)Exposure to cow's milk constitutes one of the most common causes of food allergy. In addition, exposure to soy proteins has become relevant in a restricted proportion of milk allergic pediatric patients treated with soy ...