BRAFV600E mutation in oral melanocytic nevus and oral mucosal melanoma

Abstract

Oral mucosal melanoma (OMM) is a rare and aggresive melanocytic malignant neoplasm, with incidence lower that 0.01 cases per 100.000 person-year and a worse prognosis than cutaneous melanoma. Oral melanocytic nevus (OMN) is a rare benign oral neoplasm, whose malignant transformation to OMM is debatable. The genetic basis of both lesions has been poorly explored and OMM is studied together with other mucosal melanomas as a group, despite being a separate entity....