HIV Coinfection Is Associated with low-fitness rpoB variants in rifampicin-resistant mycobacterium tuberculosis

info:eu-repo/semantics/article

Fecha

2020

Registro en:

https://hdl.handle.net/20.500.12866/8729

https://doi.org/10.1128/AAC.00782-20

Institución

Universidad Peruana Cayetano Heredia (Perú)

Resumen

We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity.

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