Perú | info:eu-repo/semantics/article
dc.date.accessioned2019-02-06T14:52:40Z
dc.date.available2019-02-06T14:52:40Z
dc.date.created2019-02-06T14:52:40Z
dc.date.issued2015
dc.identifierhttps://hdl.handle.net/20.500.12866/5354
dc.identifierhttps://doi.org/10.1111/jop.12385
dc.description.abstractBACKGROUND: Cyclooxygenase-2 (COX-2) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data about the expression of this protein in oral melanocytic lesions are available to date. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions. METHODS: COX-2 was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 36 intramucosal nevi and 13 primary oral melanomas, and in four cutaneous nevi and eight melanomas. RESULTS: All cases of oral and cutaneous melanomas were positive for COX-2. On the other hand, all oral and cutaneous melanocytic nevi were negative. CONCLUSION: COX-2 is highly positive in oral melanomas and negative in oral nevi and might represent a useful marker to distinguish melanocytic lesions of the oral cavity.
dc.languageeng
dc.publisherWiley
dc.relationJournal of Oral Pathology and Medicine
dc.relation1600-0714
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectImmunohistochemistry
dc.subjectAdolescent
dc.subjectAdult
dc.subjectFemale
dc.subjectHumans
dc.subjectYoung Adult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectBiomarkers, Tumor/biosynthesis
dc.subjectcutaneous melanocytic nevi
dc.subjectcutaneous melanoma
dc.subjectCyclooxygenase 2/biosynthesis
dc.subjectcyclooxygenase-2
dc.subjectintramucosal melanocytic nevi
dc.subjectMelanocytes/enzymology/pathology
dc.subjectMelanoma/diagnostic imaging/enzymology/pathology
dc.subjectMouth Mucosa/diagnostic imaging/enzymology/pathology
dc.subjectMouth Neoplasms/diagnostic imaging/enzymology/pathology
dc.subjectNevus/diagnostic imaging/enzymology/pathology
dc.subjectoral melanoma
dc.subjectSkin Neoplasms/diagnostic imaging/enzymology/pathology
dc.titleImmunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma
dc.typeinfo:eu-repo/semantics/article


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