Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of

dc.date.accessioned2019-02-06T14:45:59Z
dc.date.available2019-02-06T14:45:59Z
dc.date.created2019-02-06T14:45:59Z
dc.date.issued2016
dc.identifierhttps://hdl.handle.net/20.500.12866/5160
dc.identifierhttps://doi.org/10.1186/s13024-016-0076-5
dc.description.abstractBACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine phosphorylation-dependent mechanism. RESULTS: Here we report that the Src family kinases (SFKs) Fyn and Yes act downstream of PrP-1 to prevent the endocytosis and degradation of
dc.languageeng
dc.publisherSpringer
dc.relationMolecular Neurodegeneration
dc.relation1750-1326
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEndocytosis
dc.subjectAmyloid beta-Peptides/metabolism
dc.subjectAnimals
dc.subjectbeta Catenin/metabolism
dc.subjectCadherins/metabolism
dc.subjectCell Adhesion/physiology
dc.subjectCell Membrane/metabolism
dc.subjectNeurons/metabolism
dc.subjectPrions/metabolism
dc.subjectProtein Binding
dc.subjectProteolysis
dc.subjectSignal Transduction/physiology
dc.subjectsrc-Family Kinases/metabolism
dc.subjectZebrafish/metabolism
dc.titleActivation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
dc.typeinfo:eu-repo/semantics/article


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