Article
Neurodesarrollo en el hipotiroidismo congénito y sus particularidades electroencefalográficas
Fecha
2016-12Autor
Calle Ulloa, Boris Eduardo
Calle Saquipay, Ángel Domingo
Hurtado Matute, Johanna Alexandra
Cobos Castro, Johanna Elizabeth
Pinos Brito, María Carmen
Institución
Resumen
Congenital hypothyroidism (CH) is a result of a deficiency
of thyroid hormone (TH) by altering thyroid (primary
hypothyroidism), or pituitary causes (secondary hypothyroidism)
or hypothalamic (tertiary hypothyroidism).
Thyroid hormone at the tissue level, is involved in the
maturation and functional differentiation of various organs
such as the development of the central nervous
system (CNS), in which an insufficient supply of HT in time
and place, resulting in permanent abnormalities, history
highlighting the irreversible intellectual deficit. In the
world’s population it has been estimated a frequency
of 1: 300 to 1: 4000 newborns. The treatment is oral supplementation
with thyroxin.
OBJECTIVE: To describe the neurodevelopmental congenital
hypothyroidism and electroencephalographic
characteristics.
MATERIALS AND METHOD: It is an observational, descriptive
and cross-sectional study in preschool children
diagnosed with HC, who were administered the Denver
II scale, a comprehensive neurological evaluation and
a digital electroencephalogram.
RESULTS: A total of 12 patients, 7 (58%) female and 5
(42%) males were evaluated. All patients were evaluated
by the scale of Denver II, 4 (33%) were delayed in
their psychomotor development, predominantly in the
language area. Regarding the neuro-pediatric assessment
was found that 5 patients had neurological manifestations
and perform digital electroencephalogram 7
(59%) had electroencephalographic changes, 5 (71%)
showed immaturity and 2 (29%) dysfunction.
CONCLUSIONS: Afer the analysis made throughout this
investigation, the conclusions are:
The results of this study show a heterogeneous pattern,
however target the possible association between clinical
manifestations and electroencephalographic findings.
Patients with congenital hypothyroidism present a condition
in the area of language which was determined
by applying the scale Denver II.
The abnormal clinical manifestations are mainly in the
verbal area, but they are also presented as subtle manifestations
or unspecific as inattention, irritability and
behavioral disorders.
Keywords: Congenital Hypothyroidism, Neurodevelopmental
Disorders, Neurologic Manifestations, electroencephalography