ARTÍCULO
Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker
Fecha
2018Autor
Sanchez Vega, Juan Fernando
Murillo Bacilio, Magdali Del rocio
Vintimilla Condoy, Adrian Santiago
Palta Gonzalez, Araceli Miroslava
Crespo Astudillo, Jose Alfredo
Mora Bravo, Franklin Geovany
Institución
Resumen
Background: Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis equation in a group of patients with ovarian cancer based on Ca-125. Methods: A 2-group comparative observational study was conducted at a single oncologic institution (SOLCA) in Cuenca-Ecuador. All patients who were diagnosed with ovarian cancer between January 1996 and December 2016 were included in the current study. Group 1 (G1) patients with the I and II International Federation of Gynecology and Obstetrics (FIGO) stage and Metastasis Group (MG), with III and IV stage, were subdivided. A logistic regression equation was performed to predict metastasis based on Logarithm of serum Ca-125 levels. Results: We included 85 cases in G1 and 64 patients in MG, with 47.8 plusmn; 15 years (G1) and 57.5 ± 13.6 years (MG) of age (P < 0.001). Mortality in G1 was 2 cases (3.1%) and 53 cases (62.4%) in MG (P < 0.001). The CA-125 serum level was 163.5 ± 236 in G1 and 1220.9 ± 1940 u / ml in MG (P < 0.001). The equation to predict metastasis = (Age*0.053) + [(Logarithm Ca-125 value) * 1.078] -8.163 with an OR 2.940 (CI 95% 2.046-4.223) P < 0.001. The sensitivity of the equation was 82.4% and the specificity was 79.7%. Conclusions: It is possible to predict the presence of metastasis in a group of patients with ovarian cancer based on Ca-125. © 2018 The Author(s).