Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia

Abstract

Staphylococcus aureus is a major cause of severe pneumonia. Multiple mechanisms of proinflammatory signaling are activated to recruit immune cells into the airway in response to S. aureus. We found that interleukin-16 (IL-16), a T cell cytokine that bind