A Novel Live Vector Group A Streptococcal emm Type 9 Vaccine Delivered Intranasally Protects Mice against Challenge Infection with emm Type 9 Group A Streptococci

Abstract

The availability of a protective vaccine against Streptococcus pyogenes (group A Streptococcus [ GAS]) is a priority for public health worldwide. Here, we have generated six live vaccine strains, each engineered to express an N-terminal M protein peptide