Ponencia
Side fenestrations provide an anchor for a stable binding of A1899 to the pore of TASK-1
Fecha
2017Institución
Resumen
A1899
is
a
potent
and
selective
antagonist
of
the
two-‐pore
domain
potassium
(K2P)
channel
TASK-‐1.
It
was
previously
reported
that
A1899
acts
as
an
open-‐channel
blocker
and
binds
to
residues
of
the
P1,
P2
regions,
the
M2,
M4
segments
and
the
halothan