Involvement of HDL receptor SR-BI-mediated vitamin E uptake in murine neural tube closure.

Abstract

SR-BI, the main HDL receptor, mediates the cellular uptake of cholesterol and vitamin E. SR-BI is present in trophoblast giants cells (TGC) during early pregnancy and 50% SR-BI-deficient (SR-BI / ) embryos die due to defective neural tube closure (NTD). O