dc.creatorCatalán, Mabel
dc.creatorCastro-Castillo, Vicente
dc.creatorGajardo-de la Fuente, Javier
dc.creatorFerreira, Jorge
dc.creatorOlmedo, Ivonne
dc.creatorMolina-Berrios, Alfredo
dc.creatorAguilera, Jocelyn
dc.creatorPalominos, Charlotte
dc.creatorValencia, Marcelo
dc.creatorDomínguez, Marta
dc.creatorRamires-Fernandez, Ricardo [Chile. Universidad Mayor]
dc.creatorSouto, José A.
dc.creatorJara, José A.
dc.date.accessioned2021-03-01T20:21:25Z
dc.date.accessioned2022-10-18T18:43:01Z
dc.date.available2021-03-01T20:21:25Z
dc.date.available2022-10-18T18:43:01Z
dc.date.created2021-03-01T20:21:25Z
dc.date.issued2020-10-01
dc.identifierCatalán, M., Castro-Castillo, V., Gajardo-de la Fuente, J., Aguilera, J., Ferreira, J., Ramires-Fernandez, R., Olmedo, I., Molina-Berríos, A., Palominos, C., Valencia, M., Domínguez, M., Souto, J. A., & Jara, J. A. (2020). Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines. RSC medicinal chemistry, 11(10), 1210–1225. https://doi.org/10.1039/d0md00153h
dc.identifiereISSN: 2632-8682
dc.identifierhttp://repositorio.umayor.cl/xmlui/handle/sibum/7382
dc.identifierhttps://doi.org/10.1039/d0md00153h
dc.identifierhttps://pubs.rsc.org/en/content/articlelanding/2020/MD/D0MD00153H#!divAbstract
dc.identifier10.1039/d0md00153h
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4455161
dc.description.abstractContinuous flow chemistry was used for the synthesis of a series of delocalized lipophilic triphenylphosphonium cations (DLCs) linked by means of an ester functional group to several hydroxylated benzoic acid derivatives and evaluated in terms of both reaction time and selectivity. The synthesized compounds showed cytotoxic activity and selectivity in head and neck tumor cell lines. The mechanism of action of the molecules involved a mitochondrial uncoupling effect and a decrease in both intracellular ATP production and apoptosis induction.
dc.languageen_US
dc.publisherRoyal Society of Chemistry
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceRSC medicinal chemistry, 11(10), 1210–1225
dc.subjectIN-VIVO
dc.subjectDERIVATIVES
dc.subjectRESISTANCE
dc.subjectBATCH
dc.titleContinuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines
dc.typeArtículos de revistas


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