Artículos de revistas
Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines
Fecha
2020-10-01Registro en:
eISSN: 2632-8682
10.1039/d0md00153h
Autor
Catalán, Mabel
Castro-Castillo, Vicente
Gajardo-de la Fuente, Javier
Ferreira, Jorge
Olmedo, Ivonne
Molina-Berrios, Alfredo
Aguilera, Jocelyn
Palominos, Charlotte
Valencia, Marcelo
Domínguez, Marta
Ramires-Fernandez, Ricardo [Chile. Universidad Mayor]
Souto, José A.
Jara, José A.
Institución
Resumen
Continuous flow chemistry was used for the synthesis of a series of delocalized lipophilic triphenylphosphonium cations (DLCs) linked by means of an ester functional group to several hydroxylated benzoic acid derivatives and evaluated in terms of both reaction time and selectivity. The synthesized compounds showed cytotoxic activity and selectivity in head and neck tumor cell lines. The mechanism of action of the molecules involved a mitochondrial uncoupling effect and a decrease in both intracellular ATP production and apoptosis induction.