Artículos de revistas
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
Fecha
2018-01Registro en:
Krasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience, 21(1), 24-28.
1097-6256
eISSN: 1546-1726
10.1038/s41593-017-0031-y
Autor
Krasnow, Anna M.
Ford, Marc C.
Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]
Wilson, Stephen W.
Attwell, David
Institución
Resumen
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development.