Artículos de revistas
Calcium & ROS: Two orchestra directors for the requiem of death
Fecha
2020Registro en:
SanMartín, C. D., Böhme, D., & Rojas-Rivera, D. (2020). Calcium & ROS: Two orchestra directors for the requiem of death. Cell Calcium, 85, 102113.
0143-4160
1532-1991
DOI: 10.1016/j.ceca.2019.102113
Autor
Rojas-Rivera, Diego [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]
Bohme, Daniela [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]
SanMartin, Carol D. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]
Institución
Resumen
Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion.