Artículos de revistas
Gadolinium Chloride Rescues Niemann-Pick Type C Liver Damage
Fecha
2018Registro en:
Klein, A. D., Oyarzún, J. E., Cortez, C., & Zanlungo, S. (2018). Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage. International journal of molecular sciences, 19(11), 3599.
1422-0067
DOI: 10.3390/ijms19113599
Autor
Cortez, Cristián [Univ Mayor, Fac Sci, Ctr Genom & Bioinformat, Santiago 8580745, Chile]
Klein, Andrés D.
Esteban Oyarzún, Juan
Zanlungo, Silvana
Institución
Resumen
Niemann-Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive hepatosplenomegaly and cholestatic signs. Histopathologically, the liver presents with large numbers of foam cells; however, their role in disease pathogenesis has not been explored in depth. Here, we studied the consequences of gadolinium chloride (GdCl3) treatment, a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo. GdCl3 treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68A marker of Kupffer cells in the liverand normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells. Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts. This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease. Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.