dc.creator | González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim, Santiago, Chile] | |
dc.creator | Barrera, Cynthia | |
dc.creator | Valenzuela, Rodrigo | |
dc.creator | Angel Rincón, Miguel | |
dc.creator | Espinosa, Alejandra | |
dc.creator | Echeverria, Francisca | |
dc.creator | Romero, Nalda | |
dc.creator | Videla, Luis A. | |
dc.date.accessioned | 2020-04-08T14:11:55Z | |
dc.date.accessioned | 2020-04-13T18:12:37Z | |
dc.date.accessioned | 2022-10-18T18:40:49Z | |
dc.date.available | 2020-04-08T14:11:55Z | |
dc.date.available | 2020-04-13T18:12:37Z | |
dc.date.available | 2022-10-18T18:40:49Z | |
dc.date.created | 2020-04-08T14:11:55Z | |
dc.date.created | 2020-04-13T18:12:37Z | |
dc.date.issued | 2018 | |
dc.identifier | Barrera, C., Valenzuela, R., Rincón, M. Á., Espinosa, A., Echeverria, F., Romero, N., ... & Videla, L. A. (2018). Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. Free Radical Biology and Medicine, 126, 313-321. | |
dc.identifier | 0891-5849 | |
dc.identifier | 1873-4596 | |
dc.identifier | https://doi.org/10.1016/j.freeradbiomed.2018.08.030 | |
dc.identifier | http://repositorio.umayor.cl/xmlui/handle/sibum/6125 | |
dc.identifier | DOI: 10.1016/j.freeradbiomed.2018.08.030 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4453968 | |
dc.description.abstract | Enhanced iron levels in liver are associated with oxidative stress development and damage with increased fat accumulation. The aim of this work was to assess the hypothesis that antioxidant-rich extra virgin olive oil (AREVOO) counteracts iron-rich diet (IRD)-induced oxidative stress hindering hepatic steatosis. Male Wistar rats were fed and IRD (200 mg iron/kg diet) versus a control diet (CD; 50 mg iron/kg diet) with alternate AR-EVOO supplementation (100 mg/day) for 21 days. IRD induced liver steatosis and oxidative stress (higher levels of protein oxidation and lipid peroxidation with glutathione depletion), mitochondrial dysfunction (decreased citrate synthase and complex I and II activities) and loss of polyunsaturated fatty acids (PUFAs), with a drastic enhancement in the sterol regulatory element-binding protein-1c (SREBP-1c)/peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ratio upregulating the expression of lipogenic enzymes (acetyl-CoA carboxylase, fatty acid (FA) synthase and stearoyl desaturase 2) and downregulating those involved in FA oxidation (carnitine palmitoyl transferase and acyl-CoA oxidase) over values in the CD group. IRD also upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its target genes. AR-EVOO supplementation alone did not modify the studied parameters, however, IRD combined with AR-EVOO administration returned IRD-induced changes to baseline levels of the CD group. It is concluded that IRD-induced non-alcoholic fatty liver disease (NAFLD) is prevented by AREVOO supplementation, which might be related to the protective effects of its components such as hydroxytyrosol, oleic acid, tocopherols and/or PUFAs, thus representing a suitable anti-steatotic strategy to avoid progression into more severe stages of the disease, underlying NAFLD associated with iron overloading pathologies or obesity. | |
dc.language | en | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Free Radic. Biol. Med., OCT 2018. 126: p. 313-321 | |
dc.subject | Biochemistry & Molecular Biology; Endocrinology & Metabolism | |
dc.title | Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration | |
dc.type | Artículos de revistas | |